Boldenone effect on liver

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Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.

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    The purpose of present study was to investigate, the effects of anabolic steroid Boldenone (BOL) with eight weeks of resistance training on Structural changes in rat liver. 28 Male adult wistar rats, 12 weeks old and 228/53±7/94 g initial body weight were randomly assigned to four groups: group1: Control+Placebo(C), group2: training+Placebo(T), group3: training+BOL 2mg/kg (BOL2), and group 4: training+BOL, 5mg/kg (BOL5). The resistance training protocol consisted three exercise sessions weekly by 5 reps/3 sets of climbing a ladder (The initial weight attached was 50% of their body weight and increased with 10% per week throughout the training period) for lasted 8 weeks. At the end of the experiment, for light microscopic study Slides were prepared. Sections stained of rat's livers showed no any cell degeneration and cytoplasmic lipid vacuoles in all groups but few samples were seen. Indeed, congested blood sinusoids and cell infiltration, were seen in both BOL-treated groups but with higher in BOL-treated with higher dosage (BOL5). Hepatotoxic effects were severe in group treatment received 5 mg/kg body weight and directly depended on the doses. The present results showed that BOL has a marked adverse effect on the liver tissue, even with low– dose and resistance training. As a result, athletes should not use to enhance muscle mass and strength.

    Boldenone effect on liver

    boldenone effect on liver

    The purpose of present study was to investigate, the effects of anabolic steroid Boldenone (BOL) with eight weeks of resistance training on Structural changes in rat liver. 28 Male adult wistar rats, 12 weeks old and 228/53±7/94 g initial body weight were randomly assigned to four groups: group1: Control+Placebo(C), group2: training+Placebo(T), group3: training+BOL 2mg/kg (BOL2), and group 4: training+BOL, 5mg/kg (BOL5). The resistance training protocol consisted three exercise sessions weekly by 5 reps/3 sets of climbing a ladder (The initial weight attached was 50% of their body weight and increased with 10% per week throughout the training period) for lasted 8 weeks. At the end of the experiment, for light microscopic study Slides were prepared. Sections stained of rat's livers showed no any cell degeneration and cytoplasmic lipid vacuoles in all groups but few samples were seen. Indeed, congested blood sinusoids and cell infiltration, were seen in both BOL-treated groups but with higher in BOL-treated with higher dosage (BOL5). Hepatotoxic effects were severe in group treatment received 5 mg/kg body weight and directly depended on the doses. The present results showed that BOL has a marked adverse effect on the liver tissue, even with low– dose and resistance training. As a result, athletes should not use to enhance muscle mass and strength.

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