Boldenone effects and side effects

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Stephan Bonnar and Josh Barnett , mixed martial arts (MMA) fighters from the UFC and PRIDE Fighting Championships , have also tested positive for the banned substance. [11] After the World Extreme Cagefighting show on January 20, 2006 Muay Thai turned MMA fighter Kit Cope also tested positive for boldenone. [12] Following the Strikeforce card on June 22, 2007 former PRIDE and UFC fighter Phil Baroni tested positive for boldenone, as well as stanozolol . [13] At a K-1 WGP event in Las Vegas on August 17, 2007 two fighters, Rickard Nordstrand and Zabit Samedov , both tested positive for boldenone. [14] Alexandre Franca Nogueira tested positive for boldenone in July 2008. [15]

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Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts . [14] Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue selectivity via means of modulation of the ER. [13] [14] As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR), [14] and also as a "selective estrogen enzyme modulator" (SEEM). [15]

Boldenone effects and side effects

boldenone effects and side effects

Tibolone has tissue -selective estrogenic effects, with desirable effects in bone , the brain , and the vagina , and lack of undesirable action in the endometrium and breasts . [14] Its tissue selectivity is the result of metabolism , enzyme modulation (., of estrogen sulfatase and estrogen sulfotransferase ), and receptor modulation that vary in different target tissues, and differs mechanistically from that of selective estrogen receptor modulators (SERMs) such as tamoxifen , which produce their tissue selectivity via means of modulation of the ER. [13] [14] As such, to distinguish it from SERMs, tibolone has been described as a "selective tissue estrogenic activity regulator" (STEAR), [14] and also as a "selective estrogen enzyme modulator" (SEEM). [15]

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