The crystal structure of LSD bound in its active state to a serotonin receptor , specifically the 5-HT 2B receptor, has recently (2017) been elucidated for the first time.    The LSD-bound 5-HT 2B receptor is regarded as an excellent model system for the 5-HT 2A receptor and the structure of the LSD-bound 5-HT 2B receptor was used in the study as a template to determine the structural features necessary for the activity of LSD at the 5-HT 2A receptor.    The diethylamide moiety of LSD was found to be a key component for its activity, which is in accordance with the fact that the related lysergamide lysergic acid amide (LSA) is far less hallucinogenic in comparison.  LSD was found to stay bound to both the 5-HT 2A and 5-HT 2B receptors for an exceptionally long amount of time, which may be responsible for its long duration of action in spite of its relatively short terminal half-life.    The extracellular loop 2 leucine 209 residue of the 5-HT2B receptor forms a 'lid' over LSD that appears to trap it in the receptor, and this was implicated in the potency and functional selectivity of LSD and its very slow dissociation rate from the 5-HT 2 receptors.   
I usually use DetoNovo Stevia (no aftertaste) to sweeten coffees because my clients like it (I own a cafe processing company) and I know it’s super strong & only take a little to sweeten just about anything. It does not contain other ingredients such as Glycerine, natural flavors, dextrose or xylitol.
Be careful when you buy cheap Stevia brands because they have used cheap raw materials such as aspartame, xylitol etc. I dont want to pay less for lower quality food products for my clients.
Alternatively, sugar, mainly due to the high amount of fructose, can cause all sorts of serious diseases like obesity and diabetes.
So..better to use quality brands Not Artificial Sweeteners!
The placebo effect is related to the perceptions and expectations of the patient; if the substance is viewed as helpful, it can heal, but, if it is viewed as harmful, it can cause negative effects, which is known as the nocebo effect. In 1985, Irving Kirsch hypothesized that placebo effects are produced by the self-fulfilling effects of response expectancies, in which the belief that one will feel different leads a person to actually feel different.  According to this theory, the belief that one has received an active treatment can produce the subjective changes thought to be produced by the real treatment. Placebos can act similarly through classical conditioning , wherein a placebo and an actual stimulus are used simultaneously until the placebo is associated with the effect from the actual stimulus.  Both conditioning and expectations play a role in placebo effect,  and make different kinds of contribution. Conditioning has a longer-lasting effect,  and can affect earlier stages of information processing.  Those that think that a treatment will work display a stronger placebo effect than those that do not, as evidenced by a study of acupuncture.