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  • Citation tools Download this article to citation manager Wartolowska Karolina , Judge Andrew , Hopewell Sally , Collins Gary S , Dean Benjamin J F , Rombach Ines et al. Use of placebo controls in the evaluation of surgery: systematic review BMJ 2014; 348 :g3253
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    Aldactone is a very effective diuretic. Many performance athletes often assume it’s weak but this is normally due to a misguided assumption pertaining to their own physique. If you are truly in shape and use this diuretic, such as a competitive bodybuilder, you will appear sharper once you hit the stage. If you do not appear noticeably sharper, this simply means you were fatter than you thought. As a therapeutic diuretic, you will also find Aldactone is far more comfortable than other options, but in severe cases of hypertension and edema it’s sometimes not enough. However, there is no reason a healthy athlete should really ever need anything stronger than this diuretic, and this is good news as stronger loop-diuretics can be very damaging to the athlete’s health.

    SIDE EFFECTS:
    It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
    Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.

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