Gel for testosterone

Androgel is a gel containing testosterone. It is administered through the skin for treatment of low testosterone levels. It belongs to a class of drugs called androgens. Other testosterone replacement products include Androderm , Axiron , Testim, and Fortesta. Testosterone is the major male sex hormone responsible for the normal growth and development of the male sex organs and secondary sex characteristics. These effects include development of the prostate, penis, and scrotum; distribution of facial, pubic, chest and axillary hair; development of a deep voice and alterations in muscle mass and fat distribution. Low production of testosterone leads to erectile dysfunction , reduced sexual desire, fatigue and loss of energy, depression , regression of secondary sexual characteristics, and weakening of bones ( osteoporosis ). Androgel and other testosterone replacement products supplement or replace natural production of testosterone and reverse symptoms of low testosterone levels. The FDA approved Androgel in February 2000.

Hi Caroline. Professor Studd is quite unusual in prescribing Utrogestan for such a short period as this can be more risky in terms of thickened endometrial lining. I think he does this so that women can avoid the symptoms of progesterone intolerance. The standard recommendation is that progesterone be taken for 12-14 days a month. This is to ensure that you have a proper bleed and all the endometrial lining is shed. If you take Utrogestan for only 7 days a month you will need to be closely monitored for thickening of your endometrial lining by having more frequent vaginal ultrasounds. Professor Studd usually advises women to start taking Utrogestan on the 1st day of the calendar month as this is the simplest procedure, so you could try that. You could try and work out your cycle based on the date of your last period or if you have already started taking the EstroGel, opt for any day. If you haven’t already started, start the EstroGel and count day one of EstroGel as day one of your cycle and then start the Utrogestan on day 12. I hope that helps.

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Testosterone is metabolised to various 17-keto steroids through two different pathways. The major active metabolites of testosterone are oestradiol and dihydrotestosterone (DHT). Testosterone is metabolised to DHT by steroid 5α reductase located in the skin, liver and the urogenital tract of the male. DHT binds with greater affinity to SHBG than does testosterone. In many tissues, the activity of testosterone depends on its reduction to DHT, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription and cellular changes related to androgen action. In reproductive tissues, DHT is further metabolised to 3- α and 3-β androstanediol.

Gel for testosterone

gel for testosterone

Testosterone is metabolised to various 17-keto steroids through two different pathways. The major active metabolites of testosterone are oestradiol and dihydrotestosterone (DHT). Testosterone is metabolised to DHT by steroid 5α reductase located in the skin, liver and the urogenital tract of the male. DHT binds with greater affinity to SHBG than does testosterone. In many tissues, the activity of testosterone depends on its reduction to DHT, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription and cellular changes related to androgen action. In reproductive tissues, DHT is further metabolised to 3- α and 3-β androstanediol.

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